HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1)
نویسندگان
چکیده
منابع مشابه
HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1)
Anglesio et al. showed that a 4,6-kb transcript of HACE1 with strong expression in heart, brain, placenta, pancreas, as well as adult and fetal kidney. HACE1 expression is virtually undetectable in the SKNEP-1 Wilms' tumor cell line and in four of five additional primary Wilms' tumor cases compared with patient-matched normal kidney (Anglesio et al., 2004). Zhang et al. showed that HACE1 mRNA t...
متن کاملDifferential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.
We have analyzed the chromosome 6q21 breakpoint of a non-constitutional t(6;15)(q21;q21) rearrangement in sporadic Wilms' tumor. This identified a novel gene encoding a protein with six N-terminal ankyrin repeats linked to a C-terminal HECT ubiquitin-protein ligase domain. We therefore designated this gene HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1). HACE1 is...
متن کاملDifferential expression of a novel ankyrin containing E3 ubiquitin- protein ligase, Hace1, in sporadic Wilms’ tumour versus normal kidney
Departments of Pathology and Pediatrics, British Columbia Research Institute for Children’s and Women’s Health, and the University of British Columbia, Vancouver, BC, Canada V5Z4H4; Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, IWK Grace Health Centre, Halifax, Nova Scotia, Canada B3L3G9; Cross Cancer Institute, Edmo...
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متن کاملUbiquitylation of active Rac1 by the E3 Ubiquitin-Ligase HACE1
Rho GTPases undergo ubiquitylation and degradation via the ubiquitin-proteasome pathway. We now report in the November issue of Developmental Cell that the E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of GTP-bound Rac1. Depletion of HACE1 leads to an increase of Rac1 activity. We have proposed that HACE1 limits Rac1 activity in cells, a regulation that is usurped by some pathogenic ba...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2013
ISSN: 1768-3262
DOI: 10.4267/2042/49701